Animal model resources core

The LID-PEG Animal Resources Core, located at the Yale University School of Medicine, generates and applies animal models for asthma and COPD. Our goal is to gain insight into the mechanisms of these diseases, and to help develop safe and effective treatments.

In addition to mouse models of asthma and COPD, the Core is generating new strains of transgenic humanized and knockout mice to study mechanisms in the regulation of siglec ligand synthesis in the lung and to test glycans and gycan mimetics in the treatment of lung inflammation.

The Core uses molecular, cellular, immunological, histological and physiological techniques to analyze the effects of siglec-targeted ligands on eosinophilic and neutrophilic inflammation and the resulting pathology in experimental asthma and COPD. In addition, the Core helps prepare mouse lung epithelial cells and eosinophils for ex vivo and in vitro experiments, and provides technical support in analyzing the phenotypes and responsiveness of newly generated transgenic and knockout mice.

Dr. Zhu is an accomplished immunologist and an expert in animal models of respiratory diseases. His main research focus is molecular and cellular mechanisms of the pathogenesis of allergic inflammation, asthma, COPD, and acute lung injury. Dr. Zhu has established inflammatory lung disease mouse models including ovalbumin-induced acute and chronic allergic asthma models, lung-specific constitutive and inducible IL-13 transgenic asthma, cigarette smoke-induced acute and subchronic neutrophilic inflammation emphysema models, and an elastase-induced neutrophilic inflammation, lung injury and emphysema model. He is well versed and equipped to test mouse pulmonary function.

 

Zhou Zhu

  • Associate Professor
    Internal Medicine & Pediatrics
    Allergy and Clinical Immunology
    Yale University School of Medicine 300 Cedar Street, TAC S469B New Haven, CT 06511
  • Phone: 203-737-8335
    Email: zhou.zhu@yale.edu
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