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Publications

2016

Carr TF, Berdnikovs S, Simon HU, Bochner BS, Rosenwasser LJ. 2016. Eosinophilic bioactivities in severe asthma. World Allergy Organ J. 9:21.27386041

Mehta N, Porterfield M, Struwe WB, Heiss C, Azadi P, Rudd PM, Tiemeyer M, Aoki K. 2016. Mass spectrometric quantification of N-linked glycans by reference to exogenous standards. J Proteome Res. in press27432553

Bochner BS. 2016. "Siglec"ting the allergic response for therapeutic targeting. Glycobiology 26:546-552.26911285

Raclawska DS, Ttofali F, Fletcher AA, Harper DN, Bochner BS, Janssen WJ, Evans CM. 2016. Mucins and Their Sugars. Critical Mediators of Hyperreactivity and Inflammation. Ann Am Thorac Soc 13 Suppl 1:S98-S99.27027967

Schleimer RP, Schnaar RL, Bochner BS. 2016. Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression. Curr Opin Allergy Clin Immunol 16:24-30.26694037

Schnaar RL. 2016. Glycobiology simplified: diverse roles of glycan recognition in inflammation. J Leukoc Biol 99:825-838.27004978

2015

Angata T, Nycholat CM, Macauley MS. 2015. Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches. Trends Pharmacol Sci 36:645-660.26435210

Guo J, Yao H, Lin X, Xu H, Dean D, Zhu Z, Liu G, Sime P. 2015. IL-13 induces YY1 through the AKT pathway in lung fibroblasts. PLoS ONE 10:e0119039. 25775215

Watson DC, Wakarchuk WW, Gervais C, Durocher Y, Robotham A, Fernandes SM, Schnaar RL, Young NM, Gilbert M. 2015. Preparation of legionaminic acid analogs of sialo-glycoconjugates by means of mammalian sialyltransferases. Glycoconj J 32:729-734. 26452603

Erikson E, Wratil PR, Frank M, Ambiel I, Pahnke K, Claveria MP, Azadi P, Izquierdo-Useros N, Martinez-Picado J, Meier C, Schnaar RL, Crocker PR, Reutter W, Keppler O. 2015. Mouse Siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner. J Biol Chem 290:27345-27359. 26370074

Bochner BS. 2015. Novel Therapies for Eosinophilic Disorders. Immunol Allergy Clin North Am 35:577-598. 26209901

Luo L, Zhu G, Xu H, Yao S, Zhou G, Zhu Y, Tamada K, Huang L, Flies AD, Broadwater M, Ruff W, van Deursen JM, Melero I, Zhu Z, Chen L. 2015. B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets. PLoS One 10:e0130126. 26065426

Bantz SK, Zhu Z, Zheng T. 2015. The Role of Vitamin D in Pediatric Asthma. Ann Pediatr Child Health 3:1032. 25938135

Schnaar RL. 2015. Glycans and glycan-binding proteins in immune regulation: A concise introduction to glycobiology for the allergist. J Allergy Clin Immunol 135:609-615. 25649080

Bochner BS, Zimmermann N. 2015. Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation. J Allergy Clin Immunol 135:598-608. 25592986

Jia Y, Yu H, Fernandes SM, Wei Y, Gil AG, Motari MG, Vajn K, Stevens WW, Peters AT, Bochner BS, Kern RC, Schleimer RP, Schnaar RL. 2015. Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells. J Allergy Clin Immunol 135:799-810.

Kiwamoto T, Katoh T, Evans CM, Janssen WJ, Brummet ME, Hudson SA, Zhu Z, Tiemeyer M, Bochner BS. 2015. Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis. J Allergy Clin Immunol 135:1329-1340. 25497369

2014

Macauley MS, Arlian BM, Rillahan CD, Pang PC, Bortell N, Marcondes MC, Haslam SM, Dell A, Paulson JC. 2014. Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases. J Biol Chem 289:35149-3515825368325

Lee M, Kiefel H, LaJevic MD, Macauley MS, O'Hara E, Pan J, Paulson JC, Butcher EC. 2014. Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing. Nat Immunol. 15:982-995. 25173345

Stowell SR, Arthur CM, McBride R, Berger O, Razi N, Heimburg-Molinaro J, Rodrigues LC, Gourdine JP, Noll AJ, von GS, Smith DF, Knirel YA, Paulson JC, Cummings RD. 2014. Microbial glycan microarrays define key features of host-microbial interactions. Nat Chem Biol 10: 470-476. PMID: 24814672

Nix DB, Kumagai T, Katoh T, Tiemeyer M, Aoki K. 2014. Improved in-gel reductive beta-elimination for comprehensive O-linked and sulfo-glycomics by mass spectrometry. J Vis Exp e51840. PMID: 25489664

Kawasaki N, Rillahan CD, Cheng TY, Van R, I, Macauley MS, Moody DB, Paulson JC. 2014. Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation. J Immunol 193: 1560-1566. 25000981

Fang P, Zhou L, Zhou Y, Kolls JK, Zheng T, Zhu Z. 2014. Immune Modulatory Effects of IL-22 on Allergen-Induced Pulmonary Inflammation. PLoS One 9:e107454. PMID: 25254361

Oh SY, Brandal S, Kapur R, Zhu Z, Takemoto CM. 2014. Global microRNA expression is essential for murine mast cell development in vivo. Exp Hematol 42: 919-923. PMID: 25201754

Cho SH, Oh SY, Lane AP, Lee J, Oh MH, Lee S, Zheng T, Zhu Z. 2014. Regulation of nasal airway homeostasis and inflammation in mice by SHP-1 and Th2/Th1 signaling pathways. PLoS One 9:e103685. PMID: 25090641

Macauley MS, Crocker PR, Paulson JC. 2014. Siglec-mediated regulation of immune cell function in disease. Nat Rev Immunol 14:653-666. PMID: 25234143

Macauley MS, Arlian BM, Rillahan CD, Pang PC, Bortell N, Marcondes MC, Haslam SM, Dell A, Paulson JC. 2014. Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases. J Biol Chem 289:35149-35158. PMID: 25368325

Kiwamoto T, Brummet ME, Wu F, Motari MG, Smith DF, Schnaar RL, Zhu Z, Bochner BS. 2014. Mice deficient in the St3gal3 gene product alpha2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation. J Allergy Clin Immunol 133:240-247. PMID: 23830412

Rillahan CD, Macauley MS, Schwartz E, He Y, McBride R, Arlian BM, Rangarajan J, Fokin VV, Paulson JC. 2014. Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas. Chem Science 5:2398-2406. PMID: 24921038

Stowell SR, Arthur CM, McBride R, Berger O, Razi N, Heimburg-Molinaro J, Rodrigues LC, Gourdine JP, Noll AJ, von Gunten S, Smith DF, Knirel YA, Paulson JC, Cummings RD. 2014. Microbial glycan microarrays define key features of host-microbial interactions. Nat Chem Biol 10:470-476. PMID: 24814672

2013

Nycholat CM, Peng W, McBride R, Antonopoulos A, de Vries RP, Polonskaya Z, Finn MG, Dell A, Haslam SM, Paulson JC. 2013. Synthesis of biologically active N- and O-linked glycans with multisialylated poly-N-acetyllactosamine extensions using P. damsela α2-6 sialyltransferase. J Am Chem Soc 135:18280-18283. PMID: 24256304

Kim YS, Choi EJ, Lee WH, Choi SJ, Roh TY, Park J, Jee YK, Zhu Z, Koh YY, Gho YS, Kim YK. 2013. Extracellular vesicles, especially derived from Gram-negative bacteria, in indoor dust induce neutrophilic pulmonary inflammation associated with both Th1 and Th17 cell responses. Clin Exp Allergy 43:443-454. PMID: 23517040

Wang WL, Li HY, Zhang MS, Gao PS, He SH, Zheng T, Zhu Z, Zhou LF. 2013. Thymic stromal lymphopoietin: a promising therapeutic target for allergic diseases. Int Arch Allergy Immunol 160:18-26. PMID: 22948028

Oh MH, Oh SY, Lu J, Lou H, Myers AC, Zhu Z, Zheng T. 2013. TRPA1-Dependent pruritus in IL-13-induced chronic atopic dermatitis. J Immunol 191:5371-5382. PMID: 24140646

Sevin CM, Newcomb DC, Toki S, Han W, Sherrill TP, Boswell MG, Zhu Z, Collins RD, Boyd KL, Goleniewska K, Huckabee MM, Blackwell TS, Peebles RS Jr. 2013. Deficiency of gp91phox inhibits allergic airway inflammation. Am J Pespir Cell Mol Biol 49:396-402. PMID: 23590311

Zhou L, Oh SY, Zhou Y, Yuan B, Wu F, Oh MH, Wang Y, Takemoto C, Van Rooijen N, Zheng T, Zhu Z. 2013. SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis. PLoS One 8:e55763. PMID: 23390550

Boccuto L, Aoki K, Flanagan-Steet H, Chen CF, Fan X, Bartel F, Petukh M, Pittman A, Saul R, Chaubey A, Alexov E, Tiemeyer M, Steet R, Schwartz CE. 2013. A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation. Hum Mol Genet 23:418-433 PMID:24026681

Kano G, Almanan M, Bochner BS, Zimmermann N. 2013. Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. J Allergy Clin Immunol 132:437-445. PMID: 23684072

Kawasaki N, Vela JL, Nycholat CM, Rademacher C, Khurana A, van RN, Crocker PR, Kronenberg M, Paulson JC. 2013. Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. Proc Natl Acad Sci USA 110:7826-7831. PMID: 23610394

Kim YH, Park CS, Lim DH, Son BK, Kim JH, Ahn SH, Bochner BS, Na K, Jang TY. 2013. Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis. Am J Rhinol Allergy 27:187-191. PMID: 23710953

Kita H, Bochner BS. 2013. Biology of Eosinophils. In: Adkinson NF, Bochner BS, Busse WW, Holgate ST, Lemanske R, O'Hehir R, editors. Middleton's Allergy Principles and Practice. 8th ed. Mosby Elsevier.

Kiwamoto T, Katoh T, Tiemeyer M, Bochner BS. 2013. The role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation. Curr Opin Allergy Clin Immunol 13:106-111. PMID: 23160308

Kumagai T, Katoh T, Nix DB, Tiemeyer M, Aoki K. 2013. In-gel beta-elimination and aqueous-organic partition for improved O- and sulfoglycomics. Anal Chem 85:8692-8699. PMID: 23937624

Macauley MS, Pfrengle F, Rademacher C, Nycholat CM, Gale AJ, von DA, Paulson JC. 2013. Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis. J Clin Invest 123:3074-3083. PMID: 23722906

Mao H, Kano G, Hudson SA, Brummet M, Zimmermann N, Zhu Z, Bochner BS. 2013. Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen. PLoS One 8:e68143. PMID: 23840825

Pfrengle F, Macauley MS, Kawasaki N, Paulson JC. 2013. Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22. J Immunol 191:1724-1731. PMID: 23836061

Rillahan CD, Schwartz E, Rademacher C, McBride R, Rangarajan J, Fokin VV, Paulson JC. 2013. On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7. ACS Chem Biol 8:1417-1422 PMID: 23597400

Wang Z, Chinoy ZS, Ambre SG, Peng W, McBride R, de Vries RP, Glushka J, Paulson JC, Boons GJ. 2013. A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans. Science 341:379-383. PMID: 23888036

2012

Chen WC, Kawasaki N, Nycholat CM, Han S, Pilotte J, Crocker PR, Paulson JC. 2012. Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/CD169. PLoS One 7:e39039. PMID: 22723922

Chen WC, Sigal DS, Saven A, Paulson JC. 2012. Targeting B lymphoma with nanoparticles bearing glycan ligands of CD22. Leuk Lymphoma 53:208-210. PMID: 21756025

Cho SH, Oh SY, Zhu Z, Lee J, Lane AP. 2012. Spontaneous eosinophilic nasal inflammation in a genetically-mutant mouse: comparative study with an allergic inflammation model. PLoS One 7:e35114. PMID: 22509389

Kiwamoto T, Kawasaki N, Paulson JC, Bochner BS. 2012. Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions. Pharmacol Ther 135:327-336. PMID: 22749793

Moremen KW, Tiemeyer M, Nairn AV. 2012. Vertebrate protein glycosylation: diversity, synthesis and function. Nat Rev Mol Cell Biol 13:448-462. PMID: 22722607

Na HJ, Hamilton RG, Klion AD, Bochner BS. 2012. Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8. J Immunol Methods 383:39-46. PMID: 22683541

Na HJ, Hudson SA, Bochner BS. 2012. IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils. Cytokine 57:169-174. PMID: 22079334

North SJ, von GS, Antonopoulos A, Trollope A, MacGlashan DW, Jr., Jang-Lee J, Dell A, Metcalfe DD, Kirshenbaum AS, Bochner BS, Haslam SM. 2012. Glycomic analysis of human mast cells, eosinophils and basophils. Glycobiology 22:12-22. PMID: 21725073

Nycholat CM, Rademacher C, Kawasaki N, Paulson JC. 2012. In silico-aided design of a glycan ligand of sialoadhesin for in vivo targeting of macrophages. J Am Chem Soc 134:15696-15699. PMID: 22967315

Paulson JC, Macauley MS, Kawasaki N. 2012. Siglecs as sensors of self in innate and adaptive immune responses. Ann N Y Acad Sci 1253:37-48. PMID: 22288608

Rademacher C, Paulson JC. 2012. Glycan fingerprints: calculating diversity in glycan libraries. ACS Chem Biol 7:829-834. PMID: 22373368

Rillahan CD, Antonopoulos A, Lefort CT, Sonon R, Azadi P, Ley K, Dell A, Haslam SM, Paulson JC. 2012. Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat Chem Biol 8:661-668. PMID: 22683610

Rillahan CD, Schwartz E, McBride R, Fokin VV, Paulson JC. 2012. Click and pick: Identification of sialoside analogues for siglec-based cell targeting. Angew Chem Int Ed Engl 51:11014-11018. PMID: 23038623

Shin MK, Bochner BS. 2012. Anti-eosinophil therapeutics. Therapeutic approaches targeting siglecs. In: Jang-Lee J, Rosenberg HF, editors. Eosinophils in Health and Disease. Elsevier, Amsterdam; p 592-599.

Valent P, Gleich GJ, Reiter A, Roufosse F, Weller PF, Hellmann A, Metzgeroth G, Leiferman KM, Arock M, Sotlar K, Butterfield JH, Cerny-Reiterer S, Mayerhofer M, Vandenberghe P, Haferlach T, Bochner BS, Gotlib J, Horny HP, Simon HU, Klion AD. 2012. Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field. Expert Rev Hematol 5:157-176. PMID: 22475285

Valent P, Horny HP, Bochner BS, Haferlach T, Reiter A. 2012. Controversies and open questions in the definitions and classification of the hypereosinophilic syndromes and eosinophilic leukemias. Semin Hematol 49:171-181 PMID: 22449627

Bochner BS, Book W, Busse WW, Butterfield J, Furuta GT, Gleich GJ, Klion AD, Lee JJ, Leiferman KM, Minnicozzi M, Moqbel R, Rothenberg ME, Schwartz LB, Simon HU, Wechsler ME, Weller PF. 2012. Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD). J Allergy Clin Immunol 130: 587-596. PMID: 22935587

Wechsler ME, Fulkerson PC, Bochner BS, Gauvreau GM, Gleich GJ, Henkel T, Kolbeck R, Mathur SK, Ortega H, Patel J, Prussin C, Renzi P, Rothenberg ME, Roufosse F, Simon D, Simon HU, Wardlaw A, Weller PF, Klion AD. 2012. Novel targeted therapies for eosinophilic disorders. J Allergy Clin Immunol 130:563-571. PMID: 22935585

2011

Grader-Beck T, Boin F, von GS, Smith D, Rosen A, Bochner BS. 2011. Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease. Ann Rheum Dis 70:2218-2224. PMID: 21873333

Guo JP, Brummet ME, Myers AC, Na HJ, Rowland E, Schnaar RL, Zheng T, Zhu Z, Bochner BS. 2011. Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs. Am J Respir Cell Mol Biol 44:238-243. PMID: 20395633

Hudson SA, Herrmann H, Du J, Cox P, Haddad e, Butler B, Crocker PR, Ackerman SJ, Valent P, Bochner BS. 2011. Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression. J Clin Immunol 31:1045-1053. PMID: 21938510

Park CS, Bochner BS. 2011. Potential targeting of siglecs, mast cell inhibitory receptors, in interstitial cystitis. Int Neurourol J 15:61-63. PMID: 21811694

Rillahan CD, Paulson JC. 2011. Glycan microarrays for decoding the glycome. Annu Rev Biochem 80:797-823. PMID: 21469953

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